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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2344 | LY 344864 | LY344864 | 5-HT Receptor |
LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. | |||
T10630 | BuChE-IN-TM-10 | TM-10 | AChR |
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE), exhibiting an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, displays significant antioxidant activit... | |||
T12179 | Nav1.1 activator 1 | Others | |
Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration. | |||
T83130 | AMCPy | ||
AMCPy, a potent electron paramagnetic resonance (EPR) brain imaging agent, boasts excellent lipophilicity, facilitating its penetration through the blood-brain barrier (BBB) [1]. | |||
T38789 | BMS-984923 | ||
BMS-984923, a highly potent silent allosteric modulator (SAM) of mGluR5, demonstrates exceptional binding affinity (K i = 0.6 nM). Additionally, this compound possesses favorable oral bioavailability and blood-brain barr... | |||
T61388 | HAChE/Aβ1-42-IN-1 | ||
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa... | |||
T63995 | BuChE-IN-2 | ||
BuChE-IN-2 is an excellent inhibitor of butylcholinesterase (BuChE), acting on BuChE (IC50: 1.28 μM) and NO (IC50: 0.67 μM). BuChE-IN-2 inhibits Aβ aggregation, ROS formation and Cu2+ chelation, exhibits proper blood-bra... | |||
T22157 | TCS 2002 | ||
GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC 50 of 35 nM. GSK-3β inhibitor 9 exhibits good pharmacokinetic profiles including favorable BBB penetrati... |