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Search Results for " bbb penetration "

8

Compounds

Cat No. Product Name Synonyms Targets
T2344 LY 344864 LY344864 5-HT Receptor
LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
T10630 BuChE-IN-TM-10 TM-10 AChR
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE), exhibiting an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, displays significant antioxidant activit...
T12179 Nav1.1 activator 1 Others
Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration.
T83130 AMCPy
AMCPy, a potent electron paramagnetic resonance (EPR) brain imaging agent, boasts excellent lipophilicity, facilitating its penetration through the blood-brain barrier (BBB) [1].
T38789 BMS-984923
BMS-984923, a highly potent silent allosteric modulator (SAM) of mGluR5, demonstrates exceptional binding affinity (K i = 0.6 nM). Additionally, this compound possesses favorable oral bioavailability and blood-brain barr...
T61388 HAChE/Aβ1-42-IN-1
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa...
T63995 BuChE-IN-2
BuChE-IN-2 is an excellent inhibitor of butylcholinesterase (BuChE), acting on BuChE (IC50: 1.28 μM) and NO (IC50: 0.67 μM). BuChE-IN-2 inhibits Aβ aggregation, ROS formation and Cu2+ chelation, exhibits proper blood-bra...
T22157 TCS 2002
GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC 50 of 35 nM. GSK-3β inhibitor 9 exhibits good pharmacokinetic profiles including favorable BBB penetrati...
TargetMol